Trichormamide C Structural Confirmation through Total Synthesis and Extension to Analogs

Laurine Darcel (1) , Mahamadou Djibo (1) , Michel Gaillard (1) , Delphine Raviglione (1) , Isabelle Bonnard (1) , Bernard Banaigs (1) , Nicolas Inguimbert (1)

1 CRIOBE - Centre de recherches insulaires et observatoire de l'environnement

The growing interest in marine natural substances as potential new drugs has made total synthesis a real asset for structure confirmation. Trichormamide C (1), a cyclic lipopeptide isolated from the cyanobacteria Oscillatoria sp., is characterized by the presence of nonproteinogenic amino acids in the sequence. Trichormamide C structural confirmation was carried out through the implementation of a flexible synthesis resulting in two new analogs (3 and 4).

Domains: Organic chemistry

Laurine Darcel, Mahamadou Djibo, Michel Gaillard, Delphine Raviglione, Isabelle Bonnard, et al.. Trichormamide C Structural Confirmation through Total Synthesis and Extension to Analogs. Organic Letters, 2019, 22 (1), pp.145-149. ⟨10.1021/acs.orglett.9b04064⟩. ⟨hal-02473884⟩