Trichormamide C Structural Confirmation through Total Synthesis and Extension to Analogs

Laurine Darcel 1 Mahamadou Djibo 1 Michel Gaillard 1 Delphine Raviglione 1 Isabelle Bonnard 1 Bernard Banaigs 1 Nicolas Inguimbert 1
1 CRIOBE - Centre de recherches insulaires et observatoire de l'environnement
Abstract : The growing interest in marine natural substances as potential new drugs has made total synthesis a real asset for structure confirmation. Trichormamide C (1), a cyclic lipopeptide isolated from the cyanobacteria Oscillatoria sp., is characterized by the presence of nonproteinogenic amino acids in the sequence. Trichormamide C structural confirmation was carried out through the implementation of a flexible synthesis resulting in two new analogs (3 and 4).
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Submitted on : Tuesday, February 11, 2020 - 9:29:15 AM
Last modification on : Wednesday, February 12, 2020 - 1:46:49 AM

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Laurine Darcel, Mahamadou Djibo, Michel Gaillard, Delphine Raviglione, Isabelle Bonnard, et al.. Trichormamide C Structural Confirmation through Total Synthesis and Extension to Analogs. Organic Letters, American Chemical Society, 2019, 22 (1), pp.145-149. ⟨10.1021/acs.orglett.9b04064⟩. ⟨hal-02473884⟩

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