P. V. Sergiev, A. Y. Golovina, I. A. Osterman, M. V. Nesterchuk, O. V. Sergeeva et al., N6-Methylated Adenosine in RNA: From Bacteria to Humans, J Mol Biol, vol.428, pp.2134-2145, 2016.

J. Y. Roignant and M. , Soller, m(6)A in mRNA: An Ancient Mechanism for Fine-Tuning Gene Expression, Trends Genet, pp.380-390, 2017.

Z. Lin, P. J. Hsu, X. Xing, J. Fang, Z. Lu et al., Mettl3-/Mettl14-mediated mRNA N(6)-methyladenosine modulates murine spermatogenesis, Cell Res, vol.27, pp.1216-1230, 2017.

G. Zheng, J. A. Dahl, Y. Niu, P. Fedorcsak, C. M. Huang et al., ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility, Mol Cell, pp.18-29, 2013.

I. U. Haussmann, Z. Bodi, E. Sanchez-moran, N. P. Mongan, N. Archer et al., Soller, m(6)A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination, Nature, vol.540, pp.301-304, 2016.

T. Lence, J. Akhtar, M. Bayer, K. Schmid, L. Spindler et al., Roignant, m(6)A modulates neuronal functions and sex determination in Drosophila, Nature, vol.540, pp.242-247, 2016.

L. Shen, Z. Liang, X. Gu, Y. Chen, Z. W. Teo et al.,

, Methyladenosine RNA Modification Regulates Shoot Stem Cell Fate in Arabidopsis, Dev Cell, vol.38, pp.186-200, 2016.

B. S. Zhao, X. Wang, A. V. Beadell, Z. Lu, H. Shi et al., He, m(6)A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition, Nature, pp.475-478, 2017.

S. Zhong, H. Li, Z. Bodi, J. Button, L. Vespa et al., MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor, Plant Cell, vol.20, pp.1278-1288, 2008.

P. J. Batista, B. Molinie, J. Wang, K. Qu, J. Zhang et al., )A RNA modification controls cell fate transition in mammalian embryonic stem cells, Cell Stem Cell, vol.15, issue.6, pp.707-719, 2014.

Y. Wang, Y. Li, J. I. Toth, M. D. Petroski, Z. Zhang et al., N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells, Nat Cell Biol, vol.16, pp.191-198, 2014.

J. M. Fustin, M. Doi, Y. Yamaguchi, H. Hida, S. Nishimura et al., RNA-methylation-dependent RNA processing controls the speed of the circadian clock, Cell, pp.793-806, 2013.

N. J. Fry, B. A. Law, O. R. Ilkayeva, C. L. Holley, and K. D. Mansfield, N(6)-methyladenosine is required for the hypoxic stabilization of specific mRNAs, RNA, pp.1444-1455, 2017.

K. D. Meyer, D. P. Patil, J. Zhou, A. Zinoviev, M. A. Skabkin et al., UTR m(6)A Promotes Cap-Independent Translation, Cell, vol.5, pp.999-1010, 2015.

J. Zhou, J. Wan, X. Gao, X. Zhang, S. R. Jaffrey et al., Dynamic m(6)A mRNA methylation directs translational control of heat shock response, Nature, vol.526, pp.591-594, 2015.

C. R. Alarcon, H. Lee, H. Goodarzi, N. Halberg, and S. F. Tavazoie, N6-methyladenosine marks primary microRNAs for processing, Nature, vol.519, pp.482-485, 2015.

K. I. Zhou, M. Parisien, Q. Dai, N. Liu, L. Diatchenko et al., Methyladenosine Modification in a Long Noncoding RNA Hairpin Predisposes Its Conformation to Protein Binding, J Mol Biol, vol.428, issue.6, pp.822-833, 2016.

A. E. Arguello, A. N. Deliberto, and R. E. Kleiner, RNA Chemical Proteomics Reveals the N, vol.6

, Methyladenosine (m(6)A)-Regulated Protein-RNA Interactome, J Am Chem Soc, vol.139, pp.17249-17252, 2017.

R. R. Edupuganti, S. Geiger, R. G. Lindeboom, H. Shi, P. J. Hsu et al.,

, A) recruits and repels proteins to regulate mRNA homeostasis, Nat Struct Mol Biol, vol.24, pp.870-878, 2017.

C. Roost, S. R. Lynch, P. J. Batista, K. Qu, H. Y. Chang et al., Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification, J Am Chem Soc, vol.137, pp.2107-2115, 2015.

N. Liu, Q. Dai, G. Zheng, C. He, M. Parisien et al., N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions, Nature, vol.518, pp.560-564, 2015.

N. Liu, K. I. Zhou, M. Parisien, Q. Dai, L. Diatchenko et al., N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein, Nucleic Acids Res, vol.45, pp.6051-6063, 2017.

A. M. Hartmann, O. Nayler, F. W. Schwaiger, A. Obermeier, and S. Stamm, The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn), Mol Biol Cell, vol.10, pp.3909-3926, 1999.

P. Stoilov, I. Rafalska, and S. Stamm, YTH: a new domain in nuclear proteins, Trends Biochem Sci, vol.27, pp.495-497, 2002.

Z. Zhang, D. Theler, K. H. Kaminska, M. Hiller, P. De-la-grange et al., The YTH domain is a novel RNA binding domain, J Biol Chem, vol.285, pp.14701-14710, 2010.

J. Scutenaire, J. M. Deragon, V. Jean, M. Benhamed, C. Raynaud et al., The YTH Domain Protein ECT2 is an m6A Reader Required for Normal Trichome Branching in Arabidopsis, Plant Cell, 2018.
URL : https://hal.archives-ouvertes.fr/hal-02100408

F. Li, D. Zhao, J. Wu, and Y. Shi, Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition, Cell Res, vol.24, pp.1490-1492, 2014.

S. Luo and L. Tong, Molecular basis for the recognition of methylated adenines in RNA by the eukaryotic YTH domain, Proc Natl Acad Sci U S A, vol.111, pp.13834-13839, 2014.

D. Theler, C. Dominguez, M. Blatter, J. Boudet, and F. H. Allain, Solution structure of the YTH domain in complex with N6-methyladenosine RNA: a reader of methylated RNA, Nucleic Acids Res, vol.42, pp.13911-13919, 2014.

C. Xu, K. Liu, H. Ahmed, P. Loppnau, M. Schapira et al., Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins, J Biol Chem, vol.290, pp.24902-24913, 2015.

C. Xu, X. Wang, K. Liu, I. A. Roundtree, W. Tempel et al., Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain, Nat Chem Biol, vol.10, pp.927-929, 2014.

T. Zhu, I. A. Roundtree, P. Wang, X. Wang, L. Wang et al., Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine, Cell Res, vol.24, pp.1493-1496, 2014.

R. Tenhaken, T. Doerks, and P. Bork, DCD -a novel plant specific domain in proteins involved in development and programmed cell death, BMC Bioinformatics, vol.6, p.169, 2005.

D. P. Patil, B. F. Pickering, and S. R. Jaffrey, Reading m(6)A in the Transcriptome: m(6)A-Binding Proteins, Trends Cell Biol, vol.28, pp.113-127, 2018.

L. Kan, A. V. Grozhik, J. Vedanayagam, D. P. Patil, N. Pang et al., The m(6)A pathway facilitates sex determination in Drosophila, Nat Commun, vol.8, p.15737, 2017.

S. Ke, A. Pandya-jones, Y. Saito, J. J. Fak, C. B. Vagbo et al.,

. Darnell, A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover, Genes Dev, issue.6, pp.990-1006, 2017.

W. Xiao, S. Adhikari, U. Dahal, Y. S. Chen, Y. J. Hao et al., Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing, Mol Cell, pp.507-519, 2016.

I. A. Roundtree, G. Z. Luo, Z. Zhang, X. Wang, T. Zhou et al., He, YTHDC1 mediates nuclear export of N(6)-methyladenosine methylated mRNAs, Elife, p.6, 2017.

X. Wang, Z. Lu, A. Gomez, G. C. Hon, Y. Yue et al., N6-methyladenosine-dependent regulation of messenger RNA stability, Nature, pp.117-120, 2014.

H. Du, Y. Zhao, J. He, Y. Zhang, H. Xi et al., YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex, Nat Commun, vol.7, p.12626, 2016.

A. Hubstenberger, M. Courel, M. Benard, S. Souquere, M. Ernoult-lange et al., P-Body Purification Reveals the Condensation of Repressed mRNA Regulons, Mol Cell, pp.144-157, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02343529

H. J. Kang, S. J. Jeong, K. N. Kim, I. J. Baek, M. Chang et al., A novel protein, Pho92, has a conserved YTH domain and regulates phosphate metabolism by decreasing the mRNA stability of PHO4 in Saccharomyces cerevisiae, Biochem J, vol.457, pp.391-400, 2014.

I. Ivanova, C. Much, M. D. Giacomo, C. Azzi, M. Morgan et al., The RNA m(6)A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence, Mol Cell, vol.67, pp.1059-1067, 2017.

Y. Yang, X. Fan, M. Mao, X. Song, P. Wu et al., Extensive translation of circular RNAs driven by N(6)-methyladenosine, Cell Res, pp.626-641, 2017.

C. Zhou, B. Molinie, K. Daneshvar, J. V. Pondick, J. Wang et al., Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs, Cell Rep, vol.20, pp.2262-2276, 2017.

H. Shi, X. Wang, Z. Lu, B. S. Zhao, H. Ma et al., He, YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA, Cell Res, pp.315-328, 2017.

X. Wang, B. S. Zhao, I. A. Roundtree, Z. Lu, D. Han et al., He, N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency, Cell, pp.1388-1399, 2015.

Y. L. Weng, X. Wang, R. An, J. Cassin, C. Vissers et al.,

Q. Dore, W. Dong, P. Zheng, H. Jin, B. Wu et al., Epitranscriptomic m(6)A Regulation of Axon Regeneration in the Adult Mammalian Nervous System, Neuron, pp.313-325, 2018.

A. Li, Y. S. Chen, X. L. Ping, X. Yang, W. Xiao et al., Cytoplasmic m(6)A reader YTHDF3 promotes mRNA translation, Cell Res, vol.27, pp.444-447, 2017.

P. J. Hsu, Y. Zhu, H. Ma, Y. Guo, X. Shi et al., Ythdc2 is an N(6)-methyladenosine binding protein that regulates mammalian spermatogenesis, Cell Res, pp.1115-1127, 2017.

A. Tanabe, K. Tanikawa, M. Tsunetomi, K. Takai, H. Ikeda et al., RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1alpha mRNA is translated, Cancer Lett, vol.376, pp.34-42, 2016.

D. P. Patil, C. K. Chen, B. F. Pickering, A. Chow, C. Jackson et al., )A RNA methylation promotes XIST-mediated transcriptional repression, Nature, vol.537, issue.6, pp.369-373, 2016.

C. Zhang, Y. Chen, B. Sun, L. Wang, Y. Yang et al., )A modulates haematopoietic stem and progenitor cell specification, Nature, issue.6, pp.273-276, 2017.

S. Geula, S. Moshitch-moshkovitz, D. Dominissini, A. A. Mansour, N. Kol et al., Stem cells. m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation, Science, pp.1002-1006, 2015.

A. S. Bailey, P. J. Batista, R. S. Gold, Y. G. Chen, D. G. De-rooij et al., The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline, Elife, p.6, 2017.

D. Jain, M. R. Puno, C. Meydan, N. Lailler, C. E. Mason et al., ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2, Elife, p.7, 2018.

M. N. Wojtas, R. R. Pandey, M. Mendel, D. Homolka, R. Sachidanandam et al., Regulation of m(6)A Transcripts by the 3'-->5' RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline, Mol Cell, pp.374-387, 2017.

E. Abby, S. Tourpin, J. Ribeiro, K. Daniel, S. Messiaen et al., Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts, Nat Commun, vol.7, p.10324, 2016.

Y. Q. Soh, M. M. Mikedis, M. Kojima, A. K. Godfrey, D. G. De-rooij et al., Meioc maintains an extended meiotic prophase I in mice, PLoS Genet, vol.13, p.1006704, 2017.

Y. Xiang, B. Laurent, C. H. Hsu, S. Nachtergaele, Z. Lu et al., RNA m(6)A methylation regulates the ultraviolet-induced DNA damage response, Nature, pp.573-576, 2017.

Y. Yang, W. Huang, J. T. Huang, F. Shen, J. Xiong et al., Increased N6-methyladenosine in Human Sperm RNA as a Risk Factor for, Asthenozoospermia, Sci Rep, vol.6, p.24345, 2016.

E. M. Kennedy, H. P. Bogerd, A. V. Kornepati, D. Kang, D. Ghoshal et al., Posttranscriptional m(6)A Editing of HIV-1 mRNAs Enhances Viral Gene Expression, Cell Host Microbe, vol.19, pp.675-685, 2016.

N. Tirumuru, B. S. Zhao, W. Lu, Z. Lu, C. He et al., N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression, Elife, p.5, 2016.

N. S. Gokhale, A. B. Mcintyre, M. J. Mcfadden, A. E. Roder, E. M. Kennedy et al.,

S. S. Suthar, C. E. Bradrick, S. M. Mason, and . Horner, N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection, Cell Host Microbe, vol.20, pp.654-665, 2016.

K. Tsai, D. G. Courtney, and B. R. Cullen, Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication, PLoS Pathog, vol.14, p.1006919, 2018.

G. Lichinchi, B. S. Zhao, Y. Wu, Z. Lu, Y. Qin et al., Dynamics of Human and Viral RNA Methylation during Zika Virus Infection, vol.20, pp.666-673, 2016.

D. G. Courtney, E. M. Kennedy, R. E. Dumm, H. P. Bogerd, K. Tsai et al., Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication, Cell Host Microbe, vol.22, pp.377-386, 2017.

Y. Pan, P. Ma, Y. Liu, W. Li, and Y. Shu, Multiple functions of m(6)A RNA methylation in cancer, J Hematol Oncol, vol.11, p.48, 2018.

M. Chen, L. Wei, C. T. Law, F. H. Tsang, J. Shen et al., RNA N6-methyladenosine methyltransferase METTL3 promotes liver cancer progression through YTHDF2 dependent post-transcriptional silencing of SOCS2, Hepatology, 2017.

J. Chen, Y. Sun, X. Xu, D. Wang, J. He et al., YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells, Cell Cycle, vol.16, pp.2259-2271, 2017.

A. Tanabe, J. Konno, K. Tanikawa, and H. Sahara, Transcriptional machinery of TNF-alpha-inducible YTH domain containing 2 (YTHDC2) gene, Gene, vol.535, pp.24-32, 2014.

Z. Bodi, S. Zhong, S. Mehra, J. Song, N. Graham et al., Adenosine Methylation in Arabidopsis mRNA is Associated with the 3' End and Reduced Levels Cause Developmental Defects, Front Plant Sci, vol.3, p.48, 2012.

K. Ruzicka, M. Zhang, A. Campilho, Z. Bodi, M. Kashif et al.,

G. Zhong, N. P. Jaeger, J. Mongan, Y. Hejatko, R. G. Helariutta et al., Identification of factors required for m(6) A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI, New Phytol, vol.215, pp.157-172, 2017.

H. C. Duan, L. H. Wei, C. Zhang, Y. Wang, L. Chen et al., ALKBH10B Is an RNA N(6)-Methyladenosine Demethylase Affecting Arabidopsis Floral Transition, Plant Cell, vol.29, pp.2995-3011, 2017.

M. Martinez-perez, F. Aparicio, M. P. Lopez-gresa, J. M. Belles, J. A. Sanchez-navarro et al., Arabidopsis m(6)A demethylase activity modulates viral infection of a plant virus and the m(6)A abundance in its genomic RNAs, Proc Natl Acad Sci, vol.114, pp.10755-10760, 2017.

S. H. Ok, H. J. Jeong, J. M. Bae, J. S. Shin, S. Luan et al., Novel CIPK1-associated proteins in Arabidopsis contain an evolutionarily conserved C-terminal region that mediates nuclear localization, Plant Physiol, vol.139, pp.138-150, 2005.

B. Addepalli and A. G. Hunt, A novel endonuclease activity associated with the Arabidopsis ortholog of the 30-kDa subunit of cleavage and polyadenylation specificity factor, Nucleic Acids Res, vol.35, pp.4453-4463, 2007.

L. Wei, P. Song, Y. Wang, Z. Lu, Q. Tang et al., The m6A reader ECT2 controls trichome morphology by affecting mRNA stability in Arabidopsis, Plant Cell, 2018.

L. Arribas-hernandez, S. Bressendorff, M. H. Hansen, C. Poulsen, S. Erdmann et al., An m6A-YTH Module Controls Developmental Timing and Morphogenesis in Arabidopsis, Plant Cell, 2018.

L. Vespa, G. Vachon, F. Berger, D. Perazza, J. D. Faure et al., The immunophilin-interacting protein AtFIP37 from Arabidopsis is essential for plant development and is involved in trichome endoreduplication, Plant Physiol, vol.134, pp.1283-1292, 2004.

Q. Q. Li, Z. Liu, W. Lu, and M. Liu, Interplay between Alternative Splicing and Alternative Polyadenylation Defines the Expression Outcome of the Plant Unique OXIDATIVE TOLERANT-6 Gene, Sci Rep, vol.7, p.2052, 2017.

M. Chakrabarti and A. G. Hunt, CPSF30 at the Interface of Alternative Polyadenylation and Cellular Signaling in Plants, Biomolecules, vol.5, pp.1151-1168, 2015.

P. E. Thomas, X. Wu, M. Liu, B. Gaffney, G. Ji et al., Genome-wide control of polyadenylation site choice by CPSF30 in Arabidopsis, Plant Cell, pp.4376-4388, 2012.

M. Liu, R. Xu, C. Merrill, L. Hong, C. Von-lanken et al., Integration of developmental and environmental signals via a polyadenylation factor in Arabidopsis, PLoS One, vol.9, p.115779, 2014.

Z. Li, R. Wang, Y. Gao, C. Wang, L. Zhao et al., The Arabidopsis CPSF30-L gene plays an essential role in nitrate signaling and regulates the nitrate transceptor gene NRT1, New Phytol, vol.1, pp.1205-1222, 2017.

S. Rao, R. D. Dinkins, and A. G. Hunt, Distinctive interactions of the Arabidopsis homolog of the 30 kD subunit of the cleavage and polyadenylation specificity factor (AtCPSF30) with other polyadenylation factor subunits, BMC Cell Biol, vol.10, p.51, 2009.

S. Schwartz, D. A. Bernstein, M. R. Mumbach, M. Jovanovic, R. H. Herbst et al., Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA, Cell, vol.159, pp.148-162, 2014.

S. D. Agarwala, H. G. Blitzblau, A. Hochwagen, and G. R. Fink, RNA methylation by the MIS complex regulates a cell fate decision in yeast, PLoS Genet, vol.8, p.1002732, 2012.

M. J. Clancy, M. E. Shambaugh, C. S. Timpte, and J. A. Bokar, Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene, Nucleic Acids Res, vol.30, pp.4509-4518, 2002.

H. J. Kang, M. Chang, C. M. Kang, Y. S. Park, B. J. Yoon et al., The expression of PHO92 is regulated by Gcr1, and Pho92 is involved in glucose metabolism in Saccharomyces cerevisiae, Curr Genet, vol.60, pp.247-253, 2014.

Y. Nishizawa, M. Konno, A. Asai, J. Koseki, K. Kawamoto et al., Oncogene c-Myc promotes epitranscriptome m(6)A reader YTHDF1 expression in colorectal cancer, Oncotarget, vol.9, pp.7476-7486, 2018.

J. Li, S. Meng, M. Xu, S. Wang, L. He et al., Downregulation of N(6)-methyladenosine binding YTHDF2 protein mediated by miR-493-3p suppresses prostate cancer by elevating N(6)-methyladenosine levels, Oncotarget, vol.9, pp.3752-3764, 2018.

Z. Yang, J. Li, G. Feng, S. Gao, Y. Wang et al., MicroRNA-145 Modulates N(6)-Methyladenosine Levels by Targeting the 3'-Untranslated mRNA Region of the N(6)-Methyladenosine Binding YTH Domain Family 2 Protein, J Biol Chem, vol.292, pp.3614-3623, 2017.

O. Nayler, A. M. Hartmann, and S. Stamm, The ER repeat protein YT521-B localizes to a novel subnuclear compartment, J Cell Biol, vol.150, pp.949-962, 2000.

I. Rafalska, Z. Zhang, N. Benderska, H. Wolff, A. M. Hartmann et al., The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation, Hum Mol Genet, vol.13, pp.1535-1549, 2004.

D. Dominissini, S. Moshitch-moshkovitz, S. Schwartz, M. Salmon-divon, L. Ungar et al., Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq, Nature, pp.201-206, 2012.

H. Huang, H. Weng, W. Sun, X. Qin, H. Shi et al., Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation, Nat Cell Biol, vol.20, pp.285-295, 2018.

C. R. Alarcon, H. Goodarzi, H. Lee, X. Liu, S. Tavazoie et al., HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events, Cell, vol.162, pp.1299-1308, 2015.