Towards the total synthesis of trichormamide A, a cyclic undecapeptide

Michel Gaillard; Sanjit Das; Mahamadou Djibo; Delphine Raviglione; Christian Roumestand; Baptiste Legrand; Nicolas Inguimbert

doi:10.1016/j.tetlet.2018.09.010

Journal articles

Towards the total synthesis of trichormamide A, a cyclic undecapeptide

Michel Gaillard ^{1, 2} Sanjit Das ^{1, 2} Mahamadou Djibo ^{1, 2} Delphine Raviglione ^{1, 2} Christian Roumestand ³ Baptiste Legrand ⁴ Nicolas Inguimbert ^{1, 2}

1 CRIOBE - Centre de recherches insulaires et observatoire de l'environnement

2 LabEX CORAIL - Laboratoire d'Excellence CORAIL

3 CBS - Centre de Biochimie Structurale [Montpellier]

4 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]

Abstract : Lipocyclopeptides isolated from marine sources hold great promise as new lead for therapeutics. Here, we propose the first attempt towards the total synthesis of Trichormamide A. This synthesis will help to confirm the proposed structure of the cyclic lipopeptide.

Keywords : Solid phase peptide synthesis Laxaphycin Trichormamide Lipocyclopeptide Cyanobacteria

Document type :

Journal articles

Domain :

Chemical Sciences

Chemical Sciences / Medicinal Chemistry

Life Sciences [q-bio] / Biochemistry, Molecular Biology

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https://hal-univ-perp.archives-ouvertes.fr/hal-01906499
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Submitted on : Monday, November 29, 2021 - 5:17:25 PM
Last modification on : Friday, August 5, 2022 - 10:40:09 AM

Towards the total synthesis of trichormamide A, a cyclic undecapeptide

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Towards the total synthesis of trichormamide A, a cyclic undecapeptide

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