Towards the total synthesis of trichormamide A, a cyclic undecapeptide

Michel Gaillard Sanjit Das 1 Mahamadou Djibo Delphine Raviglione Christian Roumestand 2 Baptiste Legrand 3 Nicolas Inguimbert 4
1 CRIOBE - Centre de recherches insulaires et observatoire de l'environnement
2 CBS - Centre de Biochimie Structurale [Montpellier]
3 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
4 PMC - UMR_S 648 - Pharmacochimie Moléculaire et Cellulaire
Abstract : Lipocyclopeptides isolated from marine sources hold great promise as new lead for therapeutics. Here, we propose the first attempt towards the total synthesis of Trichormamide A. This synthesis will help to con- firm the proposed structure of the cyclic lipopeptide.
Keywords : Solid phase peptide synthesis Laxaphycin Trichormamide Lipocyclopeptide Cyanobacteria
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Journal articles
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Submitted on : Friday, October 26, 2018 - 6:43:38 PM
Last modification on : Tuesday, May 28, 2019 - 5:04:08 PM

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Michel Gaillard, Sanjit Das, Mahamadou Djibo, Delphine Raviglione, Christian Roumestand, et al.. Towards the total synthesis of trichormamide A, a cyclic undecapeptide. Tetrahedron Letters, Elsevier, 2018, 59 (41), pp.3713 - 3718. ⟨10.1016/j.tetlet.2018.09.010⟩. ⟨hal-01906499⟩

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