Towards the total synthesis of trichormamide A, a cyclic undecapeptide

Michel Gaillard (1, 2) , Sanjit Das (1, 2) , Mahamadou Djibo (1, 2) , Delphine Raviglione (1, 2) , Christian Roumestand (3) , Baptiste Legrand (4) , Nicolas Inguimbert (1, 2)

1 CRIOBE - Centre de recherches insulaires et observatoire de l'environnement
2 LabEX CORAIL - Laboratoire d'Excellence CORAIL
3 CBS - Centre de Biochimie Structurale [Montpellier]
4 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]

Lipocyclopeptides isolated from marine sources hold great promise as new lead for therapeutics. Here, we propose the first attempt towards the total synthesis of Trichormamide A. This synthesis will help to confirm the proposed structure of the cyclic lipopeptide.

Keywords: Solid phase peptide synthesis; Laxaphycin; Trichormamide; Lipocyclopeptide; Cyanobacteria

Domains: Chemical Sciences; Chemical Sciences; Medicinal Chemistry; Life Sciences [q-bio]; Biochemistry, Molecular Biology

Michel Gaillard, Sanjit Das, Mahamadou Djibo, Delphine Raviglione, Christian Roumestand, et al.. Towards the total synthesis of trichormamide A, a cyclic undecapeptide. Tetrahedron Letters, 2018, 59 (41), pp.3713 - 3718. ⟨10.1016/j.tetlet.2018.09.010⟩. ⟨hal-01906499⟩