A new family of 1,2,5-thiadiazolidine 1,1-dioxides: Synthesis, structure and antibacterial activity - Archive ouverte HAL Access content directly
Journal Articles Der pharma chemica Year : 2015

A new family of 1,2,5-thiadiazolidine 1,1-dioxides: Synthesis, structure and antibacterial activity

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Abstract

A convenient synthesis of novel N-N’-substituted 1,2,5-thiadiazolidine 1,1-dioxides starting from amino acids is reported in five step (reduction, carbamoylation-sulfamoylation, intermolecular cyclization via the Mitsunobu reaction and acylation). The newly synthesized compounds were characterized by IR, NMR and mass spectral analysis. Some of the newly synthesized compounds (4c and 4d) were examined for their antibacterial activity against several strains of Gram-positive and Gram-negative bacteria.
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Dates and versions

hal-01197166 , version 1 (11-09-2015)

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  • HAL Id : hal-01197166 , version 1

Cite

A. Amira, H. K’tir, I. Becheker, S. Ouarna, Nicolas Inguimbert, et al.. A new family of 1,2,5-thiadiazolidine 1,1-dioxides: Synthesis, structure and antibacterial activity. Der pharma chemica, 2015, 7 (7), pp.ePUB. ⟨hal-01197166⟩
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