A new family of 1,2,5-thiadiazolidine 1,1-dioxides: Synthesis, structure and antibacterial activity

A. Amira 1 H. K’tir 1 I. Becheker 2 S. Ouarna 1 Nicolas Inguimbert 3 H. Berredjem 2 M. Berredjem 1 Nour-Eddine Aouf 4
1 LAOC - Laboratory of Applied Organic Chemistry
2 Laboratory of Applied Biochemistry and Microbiology
3 CRIOBE - Centre de recherches insulaires et observatoire de l'environnement
4 Laboratoire de Chimie Bioorganique
Abstract : A convenient synthesis of novel N-N’-substituted 1,2,5-thiadiazolidine 1,1-dioxides starting from amino acids is reported in five step (reduction, carbamoylation-sulfamoylation, intermolecular cyclization via the Mitsunobu reaction and acylation). The newly synthesized compounds were characterized by IR, NMR and mass spectral analysis. Some of the newly synthesized compounds (4c and 4d) were examined for their antibacterial activity against several strains of Gram-positive and Gram-negative bacteria.
Keywords : CSI Mitsunobu reaction Cyclosulfamide Acylation Antibacterial Activity
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Journal articles
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https://hal-univ-perp.archives-ouvertes.fr/hal-01197166
Contributor : Olivier Savoyat <>
Submitted on : Friday, September 11, 2015 - 11:41:15 AM
Last modification on : Sunday, April 8, 2018 - 1:38:01 PM

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A. Amira, H. K’tir, I. Becheker, S. Ouarna, Nicolas Inguimbert, et al.. A new family of 1,2,5-thiadiazolidine 1,1-dioxides: Synthesis, structure and antibacterial activity. Der Pharma Chemica, Der Pharma Chemica, 2015, 7 (7), pp.ePUB. ⟨hal-01197166⟩

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