Abstract : A convenient synthesis of novel N-N’-substituted 1,2,5-thiadiazolidine 1,1-dioxides starting from amino acids is
reported in five step (reduction, carbamoylation-sulfamoylation, intermolecular cyclization via the Mitsunobu
reaction and acylation). The newly synthesized compounds were characterized by IR, NMR and mass spectral
analysis. Some of the newly synthesized compounds (4c and 4d) were examined for their antibacterial activity
against several strains of Gram-positive and Gram-negative bacteria.
https://hal-univ-perp.archives-ouvertes.fr/hal-01197166
Contributor : Olivier Savoyat
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Submitted on : Friday, September 11, 2015 - 11:41:15 AM
Last modification on : Sunday, April 8, 2018 - 1:38:01 PM
A. Amira, H. K’tir, I. Becheker, S. Ouarna, Nicolas Inguimbert, et al.. A new family of 1,2,5-thiadiazolidine 1,1-dioxides: Synthesis, structure and antibacterial activity. Der Pharma Chemica, Der Pharma Chemica, 2015, 7 (7), pp.ePUB. ⟨hal-01197166⟩
