Molecularly imprinted polymer cartridges coupled to high performance liquid chromatography (HPLC-UV) for simple and rapid analysis of fenthion in olive oil

Idriss Bakas 1, 2 Najwa Ben Oujji 1, 2 Georges Istamboulié 1 Sergey Piletsky 3 Elena Piletska 3 Elhabib Ait-Addi 2 Ihya Ait-Ichou 2 Thierry Noguer 1 Régis Rouillon 1
1 IMAGES - Institut de Modélisation et d'Analyse en Géo-Environnement et Santé
2 AQUAMAR - Laboratoire systèmes aquatiques, Milieu marin et continental
3 Department of Chemistry [Leicester]
Abstract : A combination of molecular modelling and a screening of the library of non-imprinted polymers (NIPs) was used to identify acrylamide as a functional monomer with high affinity towards fenthion, organophosphate insecticide, which is frequently used in the treatment of olives. A good correlation was found between the screening tests and modelling of monomer–template interactions performed using a computational approach. Acrylamide-based molecularly imprinted polymer (MIP) and non-imprinted polymer (NIP) were thermally synthesised in dimethyl formamide (porogen) using ethylene glycol dimethacrylate as a cross-linker and 1,1-azo-bis (isobutyronitrile) as an initiator. The chemical and physical properties of the prepared polymers were characterised. The binding of fenthion by the polymers was studied using solvents with different polarities. The developed MIP showed a high selectivity towards fenthion, compared to other organophosphates (dimethoate, methidathion malalthion), and allowed extraction of fenthion from olive oil samples with a recovery rate of about 96%. The extraction of fenthion using MIPs was much more effective than traditional C18 reverse-phase solid phase extraction and allowed to achieve a low detection limit (LOD) (5 µg L−1).
Keywords : Molecular modelling MIP Solid phase extraction (SPE) Selective extraction Olive oil Fenthion
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Journal articles
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https://hal-univ-perp.archives-ouvertes.fr/hal-01166208
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Submitted on : Monday, June 22, 2015 - 12:23:14 PM
Last modification on : Friday, June 21, 2019 - 7:56:04 AM

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Idriss Bakas, Najwa Ben Oujji, Georges Istamboulié, Sergey Piletsky, Elena Piletska, et al.. Molecularly imprinted polymer cartridges coupled to high performance liquid chromatography (HPLC-UV) for simple and rapid analysis of fenthion in olive oil. Talanta, Elsevier, 2014, 125, pp.313-318. ⟨10.1016/j.talanta.2014.03.020⟩. ⟨hal-01166208⟩

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