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11 C-Labeling: Intracyclic Incorporation of Carbon-11 into Heterocycles

Abstract : Labeling of heterocycles with carbon-11 is generally performed through peripheral functionalizations and more scarcely inside heterocyclic core. Such less common approach usually requires preliminary multi-step synthesis of reactive species. Herein, a cyclization reaction by direct use of cyclotron-produced [ 11 C]CO2 is described to obtain various heterocycles intracyclically labeled in only 10 minutes.
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https://hal.archives-ouvertes.fr/hal-02382036
Contributor : Thierry Billard <>
Submitted on : Monday, December 7, 2020 - 2:22:09 PM
Last modification on : Friday, December 11, 2020 - 2:23:20 PM
Long-term archiving on: : Monday, March 8, 2021 - 7:10:41 PM

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François Liger, Florence Cadarossanesaib, Thibaut Iecker, Christian Tourvieille, Didier Le Bars, et al.. 11 C-Labeling: Intracyclic Incorporation of Carbon-11 into Heterocycles. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2019, 2019 (41), pp.6968-6972. ⟨10.1002/ejoc.201901386⟩. ⟨hal-02382036⟩

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