Exercise training restores eNOS activation in the perivascular adipose tissue of obese rats: Impact on vascular function - Agropolis Accéder directement au contenu
Article Dans Une Revue Nitric Oxide: Biology and Chemistry Année : 2019

Exercise training restores eNOS activation in the perivascular adipose tissue of obese rats: Impact on vascular function

Cindy Meziat
  • Fonction : Auteur
  • PersonId : 781401
  • IdRef : 198736851
Eva Strock
  • Fonction : Auteur
Isabelle Bornard
Cyril Reboul
Connectez-vous pour contacter l'auteur

Résumé

Objective: This study evaluated in obese rats the effect of exercise training on eNOS expressed in perivascular adipose tissue (PVAT) and its consequences on vascular function. Methods: Wistar rats were divided in 3 groups: control (standard diet), obese (high fat/high sucrose diet, HFS for 15 weeks), and exercised obese (HFS diet and exercise from week 6 to week 15, HFS-Ex) rats. The eNOS-adiponectin pathway and reactive oxygen species (ROS) were evaluated. Vascular reactivity was assessed on isolated aortic rings with or without PVAT and/or endothelium and exposed or not to the conditioned media of PVAT. Results: Obesity reduced eNOS level and phosphorylation on its activation site in the PVAT and had no impact on the vascular wall. Exercise training was able to increase eNOS and P-eNOS both in the vascular wall and in the PVAT. Interestingly, this was associated with increased level of adiponectin in the PVAT and to lower ROS in the vascular wall. Finally, PVAT of HFS-Ex aorta has eNOS-dependent anticontractile effects on endothelium denuded aortic rings and has beneficial effects on the endothelium-dependent vasorelaxation to ACh.
Fichier principal
Vignette du fichier
S1089860318303537.pdf (835.07 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-02624851 , version 1 (26-10-2021)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Cindy Meziat, Doria Boulghobra, Eva Strock, Sylvain Battault, Isabelle Bornard, et al.. Exercise training restores eNOS activation in the perivascular adipose tissue of obese rats: Impact on vascular function. Nitric Oxide: Biology and Chemistry, 2019, 86, pp.63-67. ⟨10.1016/j.niox.2019.02.009⟩. ⟨hal-02624851⟩
36 Consultations
34 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More